拜糖苹和二甲双胍干预糖稳态受损病例的结果研究

目的:观察拜糖苹和二甲双胍对糖稳态受损包括糖耐量减低(IGT)和空腹血糖异常(IFG)病例的影响,为不同类型糖稳态受损病例提供更合理的预防糖尿病的方案.方法:按1999年WHO诊断标准判断的糖稳态受损病例69例,经卫生宣教,自主选择干预方案,其中饮食运动组15例,二甲双胍组28例,拜糖苹组26例.观察时间6个月,干预前后分别测空腹血糖(FPG),餐后2h血糖(2HPG),总胆固醇(TC),甘油三酯(TG).结果:饮食运动组经干预6个月,检测指标均有不同程度下降,但无统计学意义(P>0.05);两治疗组FPG及2hPG与治疗前比较有明显下降(P<0.01),对FPG控制两组无明显区别,对2hPG的控制拜糖苹组优于二甲双胍组(P<0.01),两治疗组TC、TG与治疗前对比明显下降(P<0.05).结论:在饮食运动基础上,对IFG病例建议选用二甲双胍,对IGT病例建议选用拜糖苹预防糖尿病的发生.

Study of the Results of Interventive Treatment of Impaired Glucose Homeostasis Patients with Acarbose and Metformin

Objective: To study the effect of acarbose and metformin to impaired glucose homeostasis patients include IGT and IFG and offer a more reasonable method to reduce potential diabetics.Methods:According to the WHO diagnostic criterion in 1999,69 IGH subjects were divided into three groups voluntarily from healthy education,15 cases in the diet-exercise group,28 cases in the metformin group and 26 cases in the acarbose group.The fasting plasma glucose(FPG),postprandial plasma glucose(2hPG),total cholesterol(TC) and total triglyceride(TG) were tested before and after interventive treatment in six months.Result:After six months,all indexes in the diet-exercise group decreased,but it is of no meaning of statistics.The FPG and 2hPG in the metformin group and acarbose group decreased remarkably(P<0.01).There isn't obvious difference between the metformin group and acarbose group for FPG,the 2hPG acarbose group is better than the metfoumin group.The TC and TG in the metformin group and acarbose group decreased remarkably(P<0.05).Conclusion:Base on diet and exercise,the IFG patients and IGT patients should choose metformin and acarbose respectively to prevent diabetes.