超负荷量氯吡格雷对急性心肌梗死急诊PCI后心肌微循环再灌注的影响

目的:观察急性心肌梗死(AMI)患者急诊经皮冠脉介入(PCI)前超负荷量应用硫酸氢氯吡格雷(简称氯吡格雷)对PCI术后患者心肌微循环再灌注和心功能的影响。方法:将52例成功急诊PCI的急性心梗患者随机平分为氯吡格雷超负荷剂量组(600mg组)及氯吡格雷负荷剂量组(300mg组),每组26例,术后第7天比较两组患者左室射血分数(LVEF)、术后24h的ST段抬高总和回落百分比(sumSTR%)、术后即刻的心肌呈色显像(Blush)3级获得率。结果:600mg组LVEF、sumSTR%和Blush 3级获得率均高于300mg组(P均0.05)。结论:急性心梗患者PCI术前应用超负荷量氯吡格雷可以改善术后心功能及心肌微循环再灌注。

Effects of Applying Clopidogrel of Overload Capacity on the Myocardial Microcirculation Reperfusion of the Patients with Acute Myocardial Infarction after Emergency of PCI Surgery

Objective:To observe the effects of the patients with acute myocardial infarction being given clopidogrel hydrogen sulfate(clopidogrel)of overload capacity before they receiving emergency of percutaneous coronary interventional(PCI)operation on their myocardial microcirculation reperfusion and cardiac function after PCI surgery.Method:52acute myocardial infarction patients who received successful emergency of PCI operation randomly into 26cases each of group overload-capacity clopidogrel(600mg)and group clopidogrel(300mg).Then,to compare the patients of the two groups of left ventricular ejection fraction(LVEF)of heart function,the fall percentage of ST-segment elevation sum(sumSTR%),and level 3getting rate of myocardial blush imaging(Blush)on the seventh day after PCI.Results:The values of LVEF,sumSTR%,and Blush3level 3getting rate of group overload-capacity clopidogrel 600mg were all higher than group clopidogrel 300mg(P<0.05).Conclusion:For the patients with acute myocardial infarction,to be given clopidogrel of overload capacity before PCI surgery can improve their cardiac function and myocardial microcirculation reperfusion situation after PCI.