狼疮性肾炎患者凝血纤溶指标的检测分析

目的:检测分析狼疮性肾炎患者凝血纤溶指标的变化及临床意义。方法:选择已确诊的狼疮性肾炎患者(狼疮性肾炎组)及原发性肾小球肾炎患者(肾小球肾炎组)各30例,平行检测两组凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、纤维蛋白原(FIB)及D二聚体(DD)水平以及不同病程狼疮性肾炎患者上述指标变化。结果:狼疮性肾炎组FIB、DD水平均高于肾小球肾炎组(P0.05),但PT、APTT差异无统计学意义(P0.05)。病程5年的狼疮性肾炎患者较病程≤5年的患者PT、APTT缩短,FIB增高,差异均有统计学意义(P0.05)。结论:狼疮性肾炎患者存在高凝状态,且病程延长,高凝加重。

The Clinical Significance of Coagulation and Fibrinolytic System in Lupus Nephritis Patient

Objective:To detect and analyze the change and significance of coagulation and fibrinolytic system in lupus nephritis patient.Method:The level of prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB)and D-dimer(D-D)level in 30lupus nephritis patients and 30glomerulonephritis patients were detelted,the change in different clinical courses in lupus nephritis patient was analysed.Results:The FIB and DD levels of 30lupus nephritis patients were increased compared with the glomerulonephritis patients(P<0.05),while the PT and APTT levels had no statistical significance(P>0.05).The PT and APTT levels were decreased and the FIB levels were increased in lupus nephritis patients whose course of disease≥ 5years,the difference was statistically significant(P<0.05).Conclusion:Patients with lupus nephritis have hypercoagulable state,and the abnormality of coagulation and fibrinolysis system increased with the course of the disease.