窒息新生儿凝血功能变化

目的:检测分析窒息新生儿凝血功能部分指标的变化及其临床意义。方法:回顾性分析554例新生儿凝血四项指标:凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原含量(FIB)的检查资料,分为正常新生儿组(n=32)、轻度窒息足月新生儿组(n=143)、重度窒息足月新生儿组(n=85)、早产儿组(n=215)及窒息早产儿组(n=79),分析各组PT、APTT、TT、FIB结果并作统计学比较。结果:以上各组四项指标数据经方差分析,差异有统计学意义(F值分别为8.41、13.18、7.30、3.19,P均0.05)。两两比较结果显示,与正常新生儿组比较,轻度窒息足月新生儿组PT、APTT、TT、FIB差异均无统计学意义(P0.05),早产儿组PT、TT、FIB亦无统计学差异(P0.05),只有APTT延长(P0.05);窒息早产儿组、重度窒息足月新生儿组PT、APTT、TT明显延长而FIB浓度明显降低(P均0.05)。窒息早产儿组PT、APTT、TT较早产儿组显著延长而FIB浓度降低(P均0.05)。重度窒息足月新生儿组PT、APTT较轻度窒息足月新生儿组延长,FIB水平较轻度窒息新生儿组降低,差异有统计学意义(P0.05)。结论:窒息早产儿和重度窒息足月新生儿凝血功能变化明显。

Changes of Coagulation Function in Asphyxia Newborn

Objective:To analysis changes and its clinical significance of part index about coagulation functiont in premature and asphyxia newborn.Method:Retrospective analysis of 554cases of newborn test data about coagulation four items(prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen(FIB)).The nauborn divided into normal newborn group(n=32),mild asphyxia of newborn group(n=143),severe asphyxia of newborn group(n=85),premature group(n=215)and asphyxia preterm infants group(n=79).Results:The above plasma parameters data through variance analysis,the difference was statistically significant(the F values were 8.41,13.18,7.30,3.19,P<0.05).Two two comparison of results,only mild asphyxia of newborn group of four items of coagulation were not statistically significant and normal newborn group(P>0.05);The Premature group only APTT levels were higher than normal newborn group(P<0.05);The results of PT,APTT,TT of severe asphyxia of newborn group and asphyxiapreterm infants group were higher than those of normal newborn group(P<0.05),while the result of FIB decreased(P<0.05).The results of PT,APTT,TT in asphyxia preterm infants group were higher than those of premature group,while the result of FIB was decreased(P<0.05).The results of PT,APTT in severe asphyxia of newborn group were higher than those of mild asphyxia of newborn group,while the result of FIB was decreased(P<0.05).Conclusion:Screening of four items of blood coagulation are marked changes in severe asphyxia of newborn and asphyxia preterm infant.