Effect of dioxydine and cyclophosphane on lipid peroxidation and superoxide dismutase and catalase activities in C57Bl/6 and BALB/c mice |
| |
Authors: | A D Durnev T G Sazontova N V Guseva S B Seredenin |
| |
Institution: | (1) Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow;(2) Research Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow |
| |
Abstract: | Twenty-four hours after intraperitoneal injection of cyclophosphane (40 mg/kg) and dioxydine (300 mg/kg) to C57Bl/6 mice,
liver catalase activity dropped by 29 and 23%, respectively. In BALB/c mice, dioxydine (but not cyclophosphane) reduced catalase
activity by 24%. Superoxide dismutase activity was lowered by cyclophosphane (but not dioxydine) in BALB/c mice, and by both
dioxydine and cyclophosphane in C57Bl/6 mice (by 24 and 86%, respectively). The level of 2-thiobarbituric acid (TBA)-reactive
lipid peroxidation (LPO) products in the liver of BALB/c mice treated with cyclophosphane and dioxydine increased 1.4- and
2.1-fold, respectively, while in C57Bl/6 mice it did not differ from the control. The initial rate ofin vitro-induced LPO in BALB/c mice receiving cyclophosphane and dioxydine increased 1.5- and 4-fold, respectively. In C57Bl/6 mice
both cyclophosphane and dioxydine inhibited the accumulation of TBA-reactive LPO products. On the whole, animals of the C57Bl/6
strain are more resistant to the LPO-inducing action of mutagens than BALB/c mice, despite the fact that the latter are characterized
by a higher activity of antioxidant enzymes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 5, pp. 528–532, May, 1996 |
| |
Keywords: | dioxydine cyclophosphane lipid peroxidation superoxide dismutase catalase C57Bl/6 and BALB/c mice |
本文献已被 SpringerLink 等数据库收录! |
|