糖尿病病人和健康人的血铬、尿铬含量

对83名非胰岛素依赖型糖尿病病人及24名健康人进行了血、尿铬测定。结果显示糖尿病病人的空腹血铬(39.9±17.4ppb)和血铬面积(128.6±48.5ppb/b)明显低于健康人(80.9±28.5ppb、270.6±88.4ppb/h)(P<<0.001),提示糖尿病病人可能缺铬。健康男性于馒头试验后60、120、180分钟时的血铬值明显高于空腹血铬值,而健康女性和糖尿病病人无明显波动,提示健康男性对铬的反应力较好。血铬和尿铬值随年令增大而增加,表现出老年人体内铬库对铬的释放、排泄增快。糖尿病病人的血铬与病程成反比,尿铬与病情成正比。

CHROMIUM LEVELS OF BLOOD AND URINE IN DIABETICSAND THE NORMALS

The fasting blood chromium and its area of 83 noninsulindependent diabetics and 24 normal subjects were determined. The results showed that both the fastng blood chromium concentrations (39.9±17.4ppb) and its area (128.8±48.5 ppb/h) of diabetics were significantly lower than that of normal subjects (80.9±28.5 ppb, 270.6±88.4 ppb/h) (P<0.001). It suggested that the diabetics might be lack of trivalent chromium. After steambread meal at 60, 120, 180 minutes, the blood chromium concentrations of normal males were significantly higher than that of the fasting but no any changes in the normal females and the diabetics. So that the normal males might have a good chromium-response. The blood and urine chromium level increased with the increasing of age and the chromium released and excreted from the body pool fastly in the aged. The blood chromium concentrations were decreased following the diabetes advancing and the urinary chromium level was increased in the more severe diabetes.