雷公藤多甙对实验性子宫内膜异位症大鼠的作用机制

目的探讨雷公藤多甙（Tripterygium wifordii polyglycosidium,TWP）治疗子宫内膜异位症的作用及其机制。方法采用大鼠自体子宫内膜移植建立实验性子宫内膜异位症模型,观察TWP对模型大鼠异位内膜中的TNF-α、IL-6含量以及血管内皮细胞生长因子（VEGF）表达的影响。结果与模型组比较TWP各剂量组均能明显抑制异位内膜的生长体积（P〈0.05,P〈0.01）,显著降低异位内膜中TNF-α、IL-6含量（P〈0.05,P〈0.01）,明显抑制异位内膜中VEGF表达（P〈0.05,P〈0.01）。结论 TWP能够有效抑制异位子宫内膜的种植,其机制可能与降低TNF-α、IL-6水平和抑制VEGF表达有关。

Effects of Tripterygium Wifordii Polyglycosidium on Rats with Experimental Endometriosis

Objective To explore the effect and mechanism of Tripterygium wifordii polyglycosidium（TWP） on the treatment of endometriosis.Methods To set up endometriosis model by rat self-endometria transplantation,and detect the influence of Tripterygium wifordii polyglycosidium on TNF-α,IL-6 and VEGF of endometriosis tissue.Results The pathogenesis of the endometriosis were inhibited by TWP（P〈0.05,P〈0.01）.The contents of TNF-α,IL-6 and the expressed of VEGF of endometriosis tissue were inhibited by TWP（P〈0.05,P〈0.01）.Conclusion TWP can inhibit the growth of endometrial transplants,which is relates with the depression of TNF-α,IL-6 and VEGF of endometriotic tissue.