慢性重型肝炎病原学、病变基础、性别、年龄分布与预后相关性的探讨

目的探讨慢性重型肝炎病原学、病变基础、性别、年龄分布与预后的相关性。方法回顾性总结慢性重型肝炎患者322例,分析其病原学特点、病变基础、性别、年龄分布及与预后的相关性,并进行统计学处理。结果(1)4种不同病原学模式患者的病死率间差别有显著性意义(P<0.05);(2)慢性乙型肝炎和肝硬化基础上发生的慢性重型肝炎的病死率间差异有显著性意义(P<0.05);(3)不同性别、不同发病年龄患者的病死率间差别有显著性意义(P<0.05);(4)单纯乙肝病毒感染与重叠感染患者的病死率间差别无显著性意义(P>0.05)。结论乙肝病毒呈复制状态、病变呈肝硬化基础、男性患者、年龄较大者发生慢性重型肝炎的预后不良。

Correlation between the Etiology, Pathological Change Foundation, Sex, Age Distribution and Prognosis with Chronic Severe Hepatitis

Objective To study the etiology,pathological change foundation,sex,age distribution and prognosis of chronic severe hepatitis.Methods Retrospective summary of 322 cases of chronic severe hepatitis B was performed to analyze the correlativity of the disease in the etiology characteristic,pathological change foundation,sex,age distribution with the prognosis.SPSS11.5 software Was used in statistical processing.Results There was a remarkable difference in mortality rate among the four etiological models of the hepatitis B virus infection ( P <0.05).There was a remarkable difference in mortality rate between chronic hepatitis and chronic severe hepatitis based on liver cirrhosis ( P <0.05).There was a significant difference in mortality rate among the populations of different sexes and different age distributions ( P <0.05).While there was no significant difference in mortality rate between patients with simple hepatitis B virus infection and those with super-infection ( P >0.05).Conclusion The prognoses of chronic severe hepatitis are unfavorable in those patients whose hepatitis B virus assumes the duplication condition,whose pathological change has liver cirrhosis foundation,who is male,and whose age is higher.