Disturbances of hypoxanthine metabolism in the liver of resuscitated rats

Catabolism of purine mononucleotides to hypoxanthine and xanthine in the liver is enhanced in rats resuscitated after a 6.5-min asphyxia. Reduced incorporation of¹⁴C-hypoxanthine into these nucleotides 30 min 1, and 3 days after resuscitation attests to its disturbed reutilization. This probably promotes activation of the xanthine oxidase reaction, leading to purine deficit and hyperproduction of reactive oxygen species. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 12, pp. 629–631, December, 1997