COX-2、VEGF在NSCLC中的表达及与微血管生成的关系

目的探讨肺癌组织中COX-2、VEGF的表达及与血管生成和临床病理特征的关系。方法收集85例肺癌和20例肺良性病变标本,免疫组化S-P法检测COX-2、VEGF蛋白及MVD的表达并作相关分析。结果COX-2、VEGF、MVD在肺癌中的阳性表达率显著高于肺良性病变组织(P<0.05);COX-2表达与肺癌的组织学类型、分化程度和淋巴结转移相关(P<0.05);VEGF表达与肺癌分化程度和淋巴结转移相关(P<0.05);COX-2、VEGF、MVD呈两两正相关。结论COX-2、VEGF参与了肺癌的发生发展过程,COX-2可能通过上调VEGF促进肺癌的血管新生和发生发展。

Expression of COX- 2 and VEGF in NSCLC and its relationship with angiogenesis

Objective: To investigate the expression of COX-2 and VEGF in NSCLC and its relationship with tumor angiogenesis. Methods: Total of 85 specimens of lung cancer and 20 specimens of lung benign lesion were collected,immunohistochemistry was ased to examine the expression of COX-2,VEGF and MVD. Results: The positive rate of COX-2,VEGF and MVD expression in NSCLC were all significantly higher than that in lung benign lesion. The expression of COX-2 was positively correlated with histological type,differentiation degree and lymph node metastasis of NSCLC (P<0.05). The expression of VEGF was positively related with tumor differentiation degree and lymph node metastasis (P<0.05). There was statistically significant correlation between the expression of COX-2,VEGF and MVD. Conclusion: The high expression of COX-2 and VEGF are involved in lung cancer development.COX-2 may upregulate VEGF expression,thus promote angiogenesis and lung cancer development.