| 乳腺癌中VEGF的表达及其临床意义 |
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| 引用本文： | 曹荣华,袁宏银,杨国梁. 乳腺癌中VEGF的表达及其临床意义[J]. 肿瘤防治研究, 2002, 29(5): 400-402 |
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| 作者姓名： | 曹荣华 袁宏银 杨国梁 |
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| 作者单位： | 1. 华中科技大学同济医学院附属同济医院器官移植研究所,武汉,430030
2. 武汉大学医学院附属中南医院肿瘤科 |
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| 摘 要： | 目的 分析乳腺癌中血管内皮生长因子 (VEGF)的表达状况及其对预后的影响。方法 检测5 8例乳腺癌组织切片中VEGF及增殖细胞核抗原 (PCNA)的表达状况 ,统计分析VEGF表达与PCNA、雌激素受体 (ER)表达的关系 ,与乳腺癌组织学分级的关系 ,并结合临床随访资料进行生存分析。结果 VEGF阳性表达 33/ 5 8,组织学分级Ⅰ级与Ⅱ级、Ⅲ级之间VEGF表达有显著性差异 ,P =0 .0 37,VEGF表达阳性组PCNA的表达显著高于阴性组且其生存时间显著低于后者 ;COX模型比例风险回归分析显示 ,VEGF表达是影响乳腺癌预后的独立因素之一。结论 乳腺癌中VEGF的表达显著影响预后 ,是独立的预后因子 .
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| 关 键 词： | 乳腺癌 VEGF 免疫组化 预后 |
| 文章编号： | 1000-8578(2002)05-0400-03 |
| 收稿时间： | 2002-03-25 |
| 修稿时间： | 2002-03-25 |
Expression of VEGF and its significance in breast cancer |
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| CAO Rong-hua,YUAN Hong-yin,YANG Guo-liang Institute of Organ Transplantation,Affiliated Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China. Expression of VEGF and its significance in breast cancer[J]. Cancer Research on Prevention and Treatment, 2002, 29(5): 400-402 |
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| Authors: | CAO Rong-hua YUAN Hong-yin YANG Guo-liang Institute of Organ Transplantation Affiliated Tongji Hospital Tongji Medical College Huazhong University of Science Technology Wuhan China |
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| Affiliation: | CAO Rong-hua,YUAN Hong-yin,YANG Guo-liang Institute of Organ Transplantation,Affiliated Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China |
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| Abstract: | Objective To research the expression of VEGF and it's influence to prognosis to breast cancer. Methods A retrospective analysis of the breast cancer tissue was examined immunohistochemically for VEGF and PCNA,and the data were analysed by SPSS statistic software according to clinical material . Results The positive expression of VEGF was 33/58.It was significantly higher VEGF expressing in higher histological grade and higher PCNA expessing group.However accompanied with poor prognosis.Cox proportional hazard model indicated that the positive expression of VEGF correlated positively with decreased survial(risk ratio=3.37, P =0.02). Conclusion The expression of VEGF had a significantly influence to prognosis of breast cancer,and it was a independent risk factor. |
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| Keywords: | Breast cancer VEGF Immunohistochemistry Prognosis |
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