bcl-2、ki-67和P53在肾细胞癌中的表达及临床意义

为更好地了解肾细胞癌的发病机制 ,应用免疫组化技术方法 ,检测 47例肾细胞癌中bcl_2、ki_6 7和P5 3蛋白表达 ,并分析其临床意义。结果 :bcl_2、ki_6 7和P5 3表达在不同细胞类型中无明显差异 ,病理分级中 ,bcl_2阳性率随分级升高而降低 ,ki_6 7和P5 3表达率则随分级升高而增高 ;不同临床分期中 ,ki_6 7和bcl_2表达率无统计学差别 ,但P5 3阳性率在临床I期明显高于其它各期 ;bcl_2、ki_6 7和P5 3阳性和阴性标本中 ,术后 5年生存率差异无显著性 ,但ki_6 7阳性组 5年生存率明显降低。结论 :bcl_2、ki_6 7和P5 3表达在RCC发生中有一定作用 ,但与RCC细胞分类无关 ,bcl_2表达在细胞癌变早期有一定作用 ,ki_6 7表达率升高与细胞恶性程度和预后不良有关 ,P5 3蛋白表达多出现于RCC临床早期阶段 ,故有一定诊断意义

Expressions of bcl-2 ki-67 and P53 in Renal Cell Carcimona and Their Clinic Significance''''s

In order to study the cause of renal cell carcinoma (RCC),bcl_2,ki_67 and P53 expressions were detected by immunohistochemistry in 47 cases. In different cell types,no significant differences were observed in these three proteins.In Fuhrman grades,bcl_2 positive rates were decreased as grades increased,but in both ki_67 and P53,the higher grade,the higher rates. There were no significnat differences among robson stages for bcl_2,ki_67 expressions.However,in stage one,P53 positive rate was higher than those in other stages.Also no significant differences were found between positive and negtive groups of bcl_2 and P53 for 5_year survival rate.But in ki_67 positive group,the survival rate was lower.The results show:bcl_2,ki_67 and P53 expression were not affected by RCC celluar types; bcl_2 protein plays a role mainly in early cell malignancy;ki_67 is connected with malignant and prognosis of the tumour,P53 expression occurs early clinic stage,which has the valur in diagnosis.