超声弹性成像技术对精索静脉曲张患者应用价值的Meta分析

目的 采用Meta分析评价超声弹性成像技术对精索静脉曲张(VC)患者的诊断价值。方法 检索PubMed、Embase、web of science、Cochrane图书馆、中国知网(CNKI)、万方以及维普数据库,严格按照纳入及排除标准筛选文献、提取资料并根据NOS量表进行质量评价,运用ＲevMan5.3软件对数据进行Meta分析。结果 最终纳入15篇文献,包含980例左侧VC患者及524名健康对照者,其中7篇文献报道了共计504例左侧VC患者与248名健康对照者在使用SWE检查后的睾丸剪切波速度值SWV,Meta分析汇总结果显示：VC患者睾丸硬度减低[MD=-0.02,95%CI(-0.03,-0.01),P=0.0004],差异具有统计学意义；3篇文献报道了共计160例左侧VC患者和100名健康对照者在使用SE检查后的睾丸应变比SR,Meta分析汇总结果显示：VC患者睾丸硬度减低[MD=-0.01,95%CI(-0.13, 0.12),P=0.92],差异不具有统计学意义；5篇文献报道了共计316例左侧VC患者和176名健康对照者在使用SE检查后的睾丸应变均值Mean,Meta分析汇总结果显示：VC患者睾丸硬度减低[MD=0.36,95%CI(0.12, 0.61),P=0.003],差异具有统计学意义。结论 超声弹性成像技术可能会成为精索静脉曲张患者的重要辅助检查手段。

A Meta-analysis of the value of ultrasound elastography in patients with varicocele

Objective To use the meta-analysis to evaluate the diagnostic value of ultrasound elastography in patients with varicocele (VC).Methods PubMed, Embase, web of science, Cochrane Library, CNKI, Wanfang and VIP data were searched to includeliteratures. Literature was screened in strict accordance with inclusion and exclusion criteria, data were extracted and quality evaluation was conducted according to NOS scale. Meta-analysis of data was conducted using RevMan5.3 software. Results 15 articles were finally included, including 980 patients with left VC and 524 healthy controls, of which 7 articles reported a total of 504 patients with left VC and 248 healthy controls after using SWE to examine the testicular shear wave velocity value (SWV), meta-analysis summary results show: VC patients have reduced testicular hardness [MD=-0.02,95%CI(-0.03,-0.01), P=0.0004], the difference is statistically significant;3 literatures reported the testicular strain ratio (SR) of a total of 160 patients with left VC and 100 healthy controls after using SE examination, the meta-analysis results showed that the testicular stiffness of the VC patients was reduced [MD=-0.01,95%CI(-0.13, 0.12),P= 0.92], the difference is not statistically significant; 5 literatures reported the average testicular strain value (Mean) of a total of 316 patients with left VC and 176 healthy controls after using SE examination, the meta-analysis summary results show: VC patients testicular stiffness decreased [MD=0.36, 95%CI(0.12, 0.61), P=0.003], the difference is statistically significant.Conclusion Ultrasound elastography may be an important adjunctive method in patients with varicocele.