| Abstract: | Abstract: Whole body autoradiography of albino mice 5, 20, 60 min., 4, 24 hrs and 4 days after a single intravenous injection of 14C-rifampicin showed that rifampicin and/or its metabolites were rapidly distributed into most organs. As early as 5 min. after the injection, the lung, myocardium, brown fat, salivary glands, gastrointestinal mucosa, pancreas, kidney and liver showed higher uptake than the blood. A blood-brain barrier was apparent. A very high uptake was initially observed in the liver. Most of the radioactivity had disappeared after 24 hrs, although slight activity was still seen in the liver and thyroid after 4 days. No other specific retention of toxicological interest was observed. |
