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Atypical cortical connectivity and visuospatial cognitive impairments are related in children with chromosome 22q11.2 deletion syndrome |
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| Authors: | Tony J Simon Zhongle Wu Brian Avants Hui Zhang James C Gee Glenn T Stebbins |
| Affiliation: | (1) M.I.N.D. Institute, University of California, Davis, 2825 50th Street, Sacramento, CA 95817, USA;(2) Department of Radiology, University of Pennsylvania, 3600 Market St., Philadelphia, PA 19104, USA;(3) Department of Neurological Sciences, Rush University Medical Center, 1725 W. Harrison, Chicago, IL 60612, USA |
| Abstract: | BackgroundChromosome 22q11.2 deletion syndrome is one of the most common genetic causes of cognitive impairment and developmental disability yet little is known about the neural bases of those challenges. Here we expand upon our previous neurocognitive studies by specifically investigating the hypothesis that changes in neural connectivity relate to cognitive impairment in children with the disorder. |
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