ACE基因多态性与中国人甲状腺疾病的相关性

目的 探讨血管紧张素Ⅰ转换酶（ＡＣＥ）基因多态性与中国人甲状腺疾病的相关性。方法 以ＡＣＥ基因为候选基因，随机挑选４１７例甲状腺疾病患者和１４３例正常人，用ＰＣＲ方法检ＡＣＥ基因的缺失／插入多态性。结果（１）正常对照组与各组之间的基因型及等位基因频率比较差镁无显著性意义，正常对照组与各组之间的ＤＤ＋ＤＩ／Ⅱ、ＤＩ＋Ⅱ／ＤＤ及ＤＤ／Ⅱ比较差异均无显著性意义。（２）正常人群ＡＣＥ基因型分布ＤＤ型最少，

Relationship between ACE gene polymorphism and thyroid diseases in Chinese

Objective To study the relationship between the polymorphism of angiotensin I-converting enzyme(ACE) gene and thyroid diseases in Chinese. Methods Using angiotensin I-converting enzyme(ACE) gene as a candidate gene,the ACE genotype was determined by polymerase chain reaction(PCR) in 417 patients with thyroid diseases(309 Graves disease,62 Hashimoto thyroiditis,46 simple goiter) and 143 normal controls. Results There was no association between thyroid diseases groups and normal controls in allels and genotypes of ACE( P >0.05).As compared with normal controls,DD DI/,DI /DD and DD/ in thyroid diseases groups showed no remarkable difference( P >0.05).The results demonstrated that the distribution of genotypes in our normal controls(DD genotype was less than DI and ) was the same as that of Japanese,but Author was different from Caucasian population. Conclusion There is no relationship between ACE gene polymorphism and thyroid diseases(Graves dieases,Hashimoto thyroiditis,simple goiter) in Chinese.