急性脑梗死并发代谢综合征患者HMGB1水平与脑动脉狭窄的相关性研究

目的:探讨急性脑梗死并发代谢综合征患者血清高迁移率族蛋白B1(high mobility group box-1,HMGB1)水平与脑动脉狭窄的相关性。方法:将74例急性脑梗死患者分为代谢综合征组和非代谢综合征组,分别检测血清HMGB1、甘油三酯、总胆固醇、高密度脂蛋白及低密度脂蛋白,并通过核磁共振血管成像明确有无颅内外动脉粥样硬化狭窄,计算各组的发生率。结果:代谢综合征组血清HMGB1水平明显高于非代谢综合征组(P<0.05),代谢综合征组脑动脉狭窄发生率显著高于非代谢综合征组(P<0.05),但行单因素Logistic回归分析提示脑动脉狭窄与血清HMGB1水平无显著相关性(P>0.05),而与代谢综合征有关(P<0.05)。结论:代谢综合征可能与脑动脉的粥样硬化狭窄有关,HMGB1可能参与此病理过程中,但HMGB1与脑动脉狭窄无明显相关性。

The relationship between HMGB1 and cerebral artery atherosclerotic stenosis in patients with acute cerebral infarction complicated by metabolic syndrome

Objective:To investigate the relationship between serum HMGB1 and cerebral artery atherosclerotic stenosis in patients with acute cerebral infarction complicated by metabolic syndrome(MS).Method:74 patients with acute cerebral infarction were divided into MS group and non-MS group according to the criteria of MS.The serum concentration of HMGB1,TC,TG,HDL-C and LDL-C were detected in each group,and all patients underwent magnetic resonance angiography(MRA) to reveal the cerebral artery atherosclerotic stenosis.Result:The serum concentration of HMGB1 was higher in MS group than in non-MS group,(P<0.05).The incidence of cerebral artery atherosclerotic stenosis was higher in MS group than in non-MS group,(P<0.05).The result of Logistic regression analysis demonstrated that there was no correlation between HMGB1 and cerebral artery stenosis(P>0.05),whereas MS was associated with cerebral artery stenosis.Conclusion:MS was relevant to cerebral artery stenosis.HMGB1 may play a role in the progress of cerebral artery atherosclerosis.However,HMGB1 was not significantly associated with cerebral artery stenosis.