保利尔胶囊对冠心病患者血管内皮功能和C-反应蛋白水平的影响

目的 观察保利尔胶囊对冠心病患者血管内皮功能和C-反应蛋白(CRP)的影响.方法 选择冠心病患者87例,随机分为治疗组和对照组,对照组采用常规西药治疗；治疗组在常规西药治疗的基础上加用保利尔胶囊4粒/次,3次/日,服用1个月.观察两组治疗前后血管内皮依赖性舒张功能(EDD)、血浆内皮素-1(ET-1)、一氧化氮(NO)和CRP水平等指标的变化.结果 治疗后,治疗组ET-1均明显下降(P＜0.05),NO明显升高(P＜0.05),但治疗组ET-1、NO较对照组变化更明显(P＜0.05).治疗后的肱动脉EDD,治疗组为(9.67±3.10)％较对照组(4.32±2.78)％明显改善(P＜0.05)；而肱动脉内皮非依赖性血管舒张功能(NMD)也得到明显改善(P＜0.05).结论 保利尔胶囊可使血浆ET-1水平明显下降,NO水平明显升高,EDD、NMD明显改善,CRP明显降低,提示保利尔胶囊有显著保护血管内皮功能、抑制炎症和改善临床症状的作用.

The Effects of Baolier Capsule on Vascular Endothelial Function and CRP in Coronary Artery Disease

Objective To observe the effect of Baolier Capsule on vascular endothelial function and C-reactive protein(CRP) in patients with coronary artery disease.Methods Eighty-seven patients(pts) with coronary artery disease were randomly divided into treatment group and control group.The changes of endothelium dependent dilation(EDD),plasma endothelin-1(ET-1),and nitric oxide(NO) were observed.Results NO level was significantly higher(P<0.05),but that was more significant in treatment group(P<0.05).Compared with control group,EDD in treatment group was improved remarkably[(9.67±3.10)% vs(4.32±2.78)%,P<0.05].EIDD was improved obviously in treatment group.Conclusion Baolier Capsule lowered ET-1 and CRP,and increased NO significantly.It could preserve vascular endothelial function,restrain the inflammatory response and improve the symptoms of patients.