扶正祛邪饮与替比夫定联合治疗对慢性乙型肝炎HBeAg血清转换作用的非随机对照研究临床观察 |
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引用本文: | 杨守平,陈孟峰,段小华,李世全,胡晚霞,黄志贤,郑可飞.扶正祛邪饮与替比夫定联合治疗对慢性乙型肝炎HBeAg血清转换作用的非随机对照研究临床观察[J].中西医结合肝病杂志,2012,22(1):12-14. |
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作者姓名: | 杨守平 陈孟峰 段小华 李世全 胡晚霞 黄志贤 郑可飞 |
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作者单位: | 乐清市第三人民医院肝病科 浙江乐清,325604 |
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基金项目: | 温州市科技局医学科技项目(No.Y20090442) |
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摘 要: | 目的:探讨扶正祛邪饮与替比夫定联合治疗慢性乙型肝炎的疗效,重点观察HBeAg血清转换指标。方法:96例患者按意愿分为联合组50例和对照组46例,联合组患者口服替比夫定片,1次/d,600mg/次,疗程12个月。另加服扶正祛邪饮,2次/d,150ml/次,疗程6个月;对照组患者单用替比夫定,用法和疗程与联合组相同。观察两组患者治疗前后的临床症状改善、肝功能好转、HBV DNA下降、HBeAg转阴及HBeAg/抗-HBe血清转换的效果。结果:两组患者治疗后的ALT、AST、TBil、HBeAg转阴率、HBeAg/抗-HBe血清转换率、HBV DNA转阴率,与治疗前比较差异有显著性意义(P<0.01或P<0.05);两组患者治疗后的比较,联合组在ALT水平、HBeAg转阴率、HBeAg/抗-HBe血清转换率等早期应答方面优于对照组(P<0.05),联合组HBeAg转阴率、HBeAg/抗-HBe血清转换率在治疗12月时高于对照组,但差异无统计学意义(P>0.05)。结论:扶正祛邪饮联合替比夫定片治疗慢性乙型肝炎早期疗效明显,肝功能恢复较快,且能促进HBeAg转阴和HBeAg/抗-HBe血清转换提前应答,可作为慢性乙型肝炎治疗的辅助药物。
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关 键 词: | 扶正祛邪饮 替比夫定 乙型肝炎 慢性 血清转换 |
Fuzheng Quxie drink and telbivudine combination therapy for chronic hepatitis B HBeAg seroconversion:a non-randomized clinicical study |
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Institution: | YANG SHOU-PING,CHEN MENG-FENG,DUAN XIAO-HUA,et al.Department of Liver Diseases,Leqing Third People’s Hospital(Leqing Zhejiang,325604)China |
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Abstract: | Objective:To study the Fuzheng Quxie drink and telbivudine combination therapy for chronic hepatitis B,and observe the key indicators of HBeAg seroconversion.Methods:Fuzheng Quxie drink and telbivudine were applicated the combined group,the drink was taken each morning and evening,each oral 150ml,for 6 months;telbivudine tablets taken once a day,each one(600mg),for 12 months;the control group was with telbivudine,usage,and the same treatment with the combination group.Clinical improvement,liver function,HBV DNA,HBeAg negative and HBeAg/anti-HBe seroconversion were observed after treatment.Results:ALT,AST,TBil,HBeAg seroconversion rate,HBeAg/anti-HBe seroconversion,HBV DNA negative rate after treatment,compared with before treatment were significant(P<0.01 orP<0.05);Comparing the effect of the two groups after treatment,the combined group in ALT levels,HBeAg seroconversion rate,HBeAg / anti-HBe seroconversion rate was better than the control group in the early response(P<0.05),but the difference was not statistically significant(P>0.05).Conclusion:Fuzheng Quxie drink joint telbivudine tablets has significant effect in the treatment of chronic hepatitis B,Fuzhenquxie drink can promote the recovery of liver function,promote HBeAg loss and HBeAg / anti-HBe seroconversion response in advance,and can be used as the adjuvant treatment of chronic hepatitis B. |
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Keywords: | Fuzheng Quxie drink telbivudine chronic hepatitis B seroconversion |
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