| 茵陈蒿汤对正常和多种糖尿病模型动物血糖的影响 |
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| 引用本文： | 潘竞锵,韩超,刘惠纯,杜洁伟,李皑洁.茵陈蒿汤对正常和多种糖尿病模型动物血糖的影响[J].中药材,2001,24(2):128-131. |
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| 作者姓名： | 潘竞锵 韩超 刘惠纯 杜洁伟 李皑洁 |
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| 作者单位： | 广州市中医中药研究所510130 |
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| 基金项目： | 本文是广东省中医药局资助项目(97279)部分研究,曾在2000中国药学会学术年会上宣读。 |
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| 摘 要： | 目的研究茵陈蒿汤对正常多种糖尿病模型动物血糖的影响，初步探讨其降低动物血糖的作用机制。方法采用正常小鼠模型、四氧嘧啶(ALX)致糖尿病(DM)大鼠模型、AALX-DM小鼠模型、地塞米松(DX)致胰岛素抵抗(IR)大鼠模型研究茵陈蒿汤的降糖作用。结果茵陈蒿汤能拮抗ALX诱导小鼠高血糖(P<0.01)，明显降低正常小鼠和AlX-DM模型小鼠、大鼠的FBG(P<0.05～0.01)；改善地塞米松致IR模型大鼠的lGr，降低OGTT后2hBG(P<0.01)。结论茵陈蒿汤具有磺脲类药物和双胍类药物的降糖作用。
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| 关 键 词： | 茵陈蒿汤 糖尿病 胰岛素抵抗 血糖 实验研究 |
| 修稿时间： | 2000年12月1日 |
Effects of Yinchenhao
Decoction on Normal Animals and Animal Models of Diabetes Mellitus |
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| Pan Jingqiang,Han Chao,Liu Huichun,Du Jiewei,Li Aijie.Effects of Yinchenhao
Decoction on Normal Animals and Animal Models of Diabetes Mellitus[J].Jorunal of Chinese Medicinal Materials,2001,24(2):128-131. |
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| Authors: | Pan Jingqiang Han Chao Liu Huichun Du Jiewei Li Aijie |
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| Institution: | Guangzhou Institute of Traditional Chinese Medicine & Materia Medica, Guangzhou 510130. |
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| Abstract: | Object: To study the effects of Yinchenhao Decoction on the blood glucose level in a variety of animal models and its mechanism. Methods: Nonnal mice, rats model of ailoxan (ALX)-induced diabetes melhitus (DM) , mice model of ALX-DM and rats model of dex-amethasone (DX)-induced insulin resistance (IR) were used. Results: Yinchenhao Decoction was able to inhibit the hyperglycemia by ALX-induced mice(P<0.01), significantly reduce level of FBG in nonnal mice, ALX-DM mice and rats (P<0.05-0.01), improve IGTand lower 2hBG (P<0.0l) after OGTT in DX-induced insulin-resistant rats. Conclusions: The results suggest that Yinchenhao Decoction possesses similar hypoglycemic action to meftormin and gliclazied. |
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| Keywords: | Yinchenhao Decoction Diabetes mellitus(DM) Insulin resistance(IR) Animal model Blood glucose |
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