Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia |
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| Authors: | Taketomi Takaharu Yoshiga Daigo Taniguchi Koji Kobayashi Takashi Nonami Atsushi Kato Reiko Sasaki Mika Sasaki Atsuo Ishibashi Hitoshi Moriyama Maiko Nakamura Kei-ichiro Nishimura Junji Yoshimura Akihiko |
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| Institution: | Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. |
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| Abstract: | We report here that loss of the Sprouty2 gene (also known as Spry2) in mice resulted in enteric nerve hyperplasia, which led to esophageal achalasia and intestinal pseudo-obstruction. Glial cell line-derived neurotrophic factor (GDNF) induced hyperactivation of ERK and Akt in enteric nerve cells. Anti-GDNF antibody administration corrected nerve hyperplasia in Sprouty2-deficient mice. We show Sprouty2 to be a negative regulator of GDNF for the neonatal development or survival of enteric nerve cells. |
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