儿童重症腺病毒肺炎不良预后的危险因素分析

目的探讨儿童重症腺病毒肺炎不良预后的危险因素。方法回顾性分析189例重症腺病毒肺炎患儿的临床资料,通过单因素logistic回归分析评估预后不良的危险因素。结果单因素logistic回归分析显示,血红蛋白90 g/L、白蛋白30 g/L、C-反应蛋白30 mg/L、降钙素原10 ng/m L、丙氨酸氨基转移酶100 U/L、天冬氨酸氨基转移酶100 U/L以及合并先天性气道发育异常、并发急性呼吸窘迫综合征、循环系统并发症、电解质酸碱平衡紊乱、并发3种及以上并发症者预后不良(P0.05)。结论重症腺病毒肺炎的不良预后与贫血、低白蛋白血症、炎症反应、并发多种并发症以及合并肺部基础疾病有关。

Risk factors for poor prognosis in children with severe adenovirus pneumonia

ObjectiveTo investigate the risk factors for poor prognosis of severe adenovirus pneumonia (SAP) in children.MethodsThe clinical data of 189 children with SAP were retrospectively analyzed. Univariate logistic regression analysis was performed to assess the risk factors for poor prognosis.ResultsThe univariate logistic regression analysis showed that the patients with hemoglobin <90 g/L, plasma albumin <30 g/L, C-reactive protein>30 mg/L, procalcitonin >10 ng/mL, alanine aminotransferase >100 U/L, or aspartate aminotransferase >100 U/L had poor prognosis (P<0.05), and that those with congenital dysplasia of the airway, acute respiratory distress syndrome, circulatory complications, electrolyte and acid-base disturbance, or more than three complications also had poor prognosis (P<0.05).ConclusionsPoor prognosis of severe adenovirus pneumonia in children is associated with anemia, low serum albumin, inlfammatory response, concurrent multiple complications and underlying lung diseases.