| 非小细胞肺癌血清中lncRNA HOTAIR的表达及临床意义 |
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| 引用本文： | 谭楠,李莉红,白璐,赵昆.非小细胞肺癌血清中lncRNA HOTAIR的表达及临床意义[J].中国肺癌杂志,2017(6):402-406. |
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| 作者姓名： | 谭楠 李莉红 白璐 赵昆 |
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| 作者单位： | 西安市第一医院干部病房科, 西安,710002 |
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| 摘 要： |
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| 关 键 词： | 肺肿瘤 长链非编码RNA HOX转录反义RNA 临床病理 |
Expression of Serum LncRNA HOTAIR in Non-small Cell Lung Cancer and Its Clinical Significance |
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| Nan TAN,Lihong LI,Lu BAI,Kun ZHAO.Expression of Serum LncRNA HOTAIR in Non-small Cell Lung Cancer and Its Clinical Significance[J].Chinese Journal of Lung Cancer,2017(6):402-406. |
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| Authors: | Nan TAN Lihong LI Lu BAI Kun ZHAO |
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| Abstract: | Background and objective The expression of long noncoding RNA HOX antisense RNA (HO-TAIR) is abnormal in a variety of tumors. The aim of this study is to explore the serum levels and clinical significance of HOTAIR in patients with non-small cell lung cancer (NSCLC). Methods The serum levels of HOTAIR were detected by real-time quantitative polymerase chain reaction (PCR) in 64 NSCLC patients and 64 normal controls. The rela-tionships between the serum levels of HOTAIR and clinical pathological parameters were analyzed. Results Compared with normal controls, the serum levels of HOTAIR in patients with NSCLC increased significantly (P<0.01). The serum levels of HOTAIR were correlated with tumor size, tumor-node-metastasis (TNM) stage and lymph node me-tastasis (P<0.05), but not with age, gender, smoking, differentiation and histology (P>0.05). Conclusion The serum levels of HOTAIR in patients with NSCLC are significantly higher, and HOTAIR may be involved in the pathogenesis of NSCLC. |
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