心室内舒张早期充盈减射现象一项测定心室舒张功能障碍的新指标

本项研究应用脉冲多普勒技术测定正常人和器质性心脏病（冠心病、高心病、房颤）患者二尖瓣口及瓣下１、２、３ｃｍ处心室内不同部位的舒张早期充盈速度（Ｅ_０、Ｅ_１、Ｅ_２、Ｅ_３），并分别算出各点速度与瓣口速度的比值（Ｅ_１／Ｅ_０，Ｅ_２／Ｅ_０，Ｅ_２／Ｅ_０）。发现正常人上述各点速度和比值均无显著统计学差异，而器质性心脏病组一般Ｅ_２即开始降低，Ｅ_３显著降低，Ｅ_３／Ｅ_０与自身Ｅ_０／Ｅ_０、Ｅ_２／Ｅ_０相比有显著差异（心室内减射现象），而且各组Ｅ_３／Ｅ_０比值与常规测定舒张功能的指Ｅ／Ａ法之间存在良好的相关性。作者认为Ｅ_３／Ｅ_０比值是反映心室舒张功能障碍的良好指标，可以弥补Ｅ／Ａ法的不足之处。

Intraventricular Early Diastolic Decreasing Filling Phenomena: A New Approach for Revealing Ventricular Diastolic Dysfunction

This study was designed to record mitral flow velocity(E0)and the intraventricular regional early diastolic flow velocity at 1,2, and 3 cm from mitral tip toward the apex(E1, E2 and E3)in normal control group and three heart disease patient group (coronary, hypertensive and atrial fibrillation respectively)by using pulsed Doppler echocardiography. The ratio of velocity of three points(E1, E2 and E3)t o mitral tip velocity (E0)(E1/E0, E2/E0, E3/E0) were calculated and Compared. In the normal,subjects, the above indexes had no significant difference, but in the other three groups E2 began to decrease and E3 dropped remarkblely. There were significant differences between E3/E0 and E1/E0 ,E2/E0 (intraventricular early diastolic decreasing filling phenomena, IEDDFP). Also,E3/E0 of each group related well with the old method of E/A in evaluating ventricular diastolic function. The authors concluded that E3/E0 might compensate the default of the old method E/A in the case of atrial fibrillation and was simple in the assessment of ventricular diastolic function.