酪氨酸激酶受体RON在肿瘤发生和发展中的作用

酪氨酸激酶受体(receptors tyrosine kinase,RTK)介导许多关键的细胞功能,在肿瘤的发生、发展和转移中扮演着重要的角色.RON属于RTK亚家族中成员之一,主要表达在上皮来源的细胞,其配体是巨噬细胞刺激蛋白(macrophage stimulating protein,MSP).RON活化后引起细胞转化、生长、迁移和基质侵袭.我们就RON分子结构、激活方式和致癌机制作相关阐述,并探讨RON在肿瘤中的表达,有助于肿瘤的治疗.

Recepteur d'origine nantais(RON)in tumor pathogenesis and development

Tyrosine kinase receptors mediate many critical cellular functions that contribute to tumor progression and metastasis.Recepteur d'origine nantais(RON)belongs to a subfamily of receptor tyrosine kinases(RTK)with unique expression patterns and biological activities.RON is activated by a serum-derived growth factor macrophage stimulating protein(MSP),primarily expressed in cells of epithelial origin.RON activation induced cell transformation,growth,migration and matrix invasion.We review RON molecular structure,activation,and carcinogenic mechanism related.It will contribute to cancel treatment and to discuss RON expression in the tumor.