|
|||||
|
|
| 卒中后抑郁新的病因假说——谷氨酸能障碍 | |
| 引用本文： | 岳莹莹,袁勇贵,张志珺. 卒中后抑郁新的病因假说——谷氨酸能障碍[J]. 中国卒中杂志, 2014, 9(1): 38-42 |
| 作者姓名： | 岳莹莹 袁勇贵 张志珺 |
| 作者单位： | 210009 南京东南大学附属中大医院神经精神医学科，东南大学医学院 |
| 基金项目： | 江苏省科技创新与成果转化（ 生命健康科技）专项资金（BL2012025） |
| 摘 要： | 卒中后抑郁（post-stroke depression，PSD）是卒中后常见的神经精神症状之一，以心境低落、兴趣下降为主要特征，不仅影响患者神经功能的康复，而且显著增加卒中病死率。其发病机制尚未明确，伴随离子型谷氨酸受体拮抗剂氯胺酮的快速抗抑郁作用的出现，谷氨酸（glutamate，Glu）能神经系统在抑郁症及PSD中的作用日益突出，也为抗抑郁治疗带来新的契机。 |
| 关 键 词： | 抑郁症 卒中后抑郁 谷氨酸 抗抑郁药 |
| 收稿时间： | 2013-09-18 |
Glutamate Dysfunctional Etiology Hypothesis of Post-stroke Depression |
|
| YUE Ying-Ying,YUAN Yong-Gui,ZHANG Zhi-Jun. Glutamate Dysfunctional Etiology Hypothesis of Post-stroke Depression[J]. Chinese Journal of Stroke, 2014, 9(1): 38-42 | |
| Authors: | YUE Ying-Ying YUAN Yong-Gui ZHANG Zhi-Jun |
| Affiliation: | Department of Neuropsychiatry, Affiliated Zhongda;Hospital and Institute of Neuropsychiatry of Southeast University, Nanjing 210009, China |
| Abstract: | Post-stroke depression (PSD) is one of the most common neuropsychiatric complications after stroke that is characterized by depressed mood and loss interest. It can not only affect the neurological rehabilitation, but also significantly increase the mortality of patients. However, the pathogenesis is not clear. Glutamate system plays an important role in depression and PSD and brings new opportunities for treatment along with the appearance of rapid antidepressant ketamine which is the antagonist of an ionotropic glutamate receptor. |
| Keywords: | Depression Post-stroke depression Glutamate Antidepressant |
| 本文献已被 CNKI 维普 等数据库收录！ | |
| 点击此处可从《中国卒中杂志》浏览原始摘要信息 | |
| 点击此处可从《中国卒中杂志》下载全文 | |