| 激素对精子发生的调控 |
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| 引用本文： | 崔毓桂,陈子庆,沙家豪. 激素对精子发生的调控[J]. 中华男科学杂志, 2004, 10(6): 465-467,469 |
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| 作者姓名： | 崔毓桂 陈子庆 沙家豪 |
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| 作者单位： | 1. 南京医科大学第一附属医院中心实验室,江苏,南京,210029
2. 江苏省生殖医学重点实验室,江苏,南京,210029 |
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| 基金项目： | 江苏省卫生厅"135工程"医学重点人才基金 |
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| 摘 要： | 精子发生是一个连续不断的细胞增生与分化的过程 ,是激素依赖的调控 ,其中卵泡刺激素 (FSH)和黄体生成素 (LH)刺激释放的睾酮 (T)是主要的激素调节者。睾丸内T是维持精子发生最关健的因素之一 ,而FSH对正常精子发生的起始和维持同样是必须的。在介导激素调节中 ,Sertoli细胞处于核心地位。同时 ,正常精子发生过程中的生精细胞凋亡也是激素调控的。深入研究精子发生的激素调控 ,为探索安全、可复的男性避孕方法奠定了基础。
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| 关 键 词： | 精子发生 促性腺激素 雄激素 |
| 文章编号： | 1009-3591(2004)06-0465-04 |
| 修稿时间： | 2003-08-26 |
Effects of Reproductive Hormones on Spermatogenesis |
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| Cui Yugui,Chen Ziqing,Sha Jiahao Key Laboratory,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu ,China. Effects of Reproductive Hormones on Spermatogenesis[J]. National journal of andrology, 2004, 10(6): 465-467,469 |
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| Authors: | Cui Yugui Chen Ziqing Sha Jiahao Key Laboratory the First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China |
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| Affiliation: | Key Laboratory, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China. cuiygui@njmu.edu.cn |
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| Abstract: | Spermatogenesis,a continuous course of cell proliferation and differentiation,depends on reproductive hormones. FSH and LH-induced T are the main hormones regulating spermatogensis. Intratesticular T is one of the key factors in maintaining spermatogenesis,while FSH is just as important for origination and maintenance of normal spermatogenesis. Sertoli cells are the pivot of hormonal regulation. Interestingly,these reproductive hormones also regulate sperm cell apoptosis in normal spermatogenesis. Further studies on the hormonal regulation of spermatogenesis provide a base for the development of safe and recoverable contraceptives for males. |
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| Keywords: | spermatogenesis gonadotropin androgen |
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