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ME3738 enhances the effect of interferon and inhibits hepatitis C virus replication both in vitro and in vivo |
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| Authors: | Abe Hiromi Imamura Michio Hiraga Nobuhiko Tsuge Masataka Mitsui Fukiko Kawaoka Tomokazu Takahashi Shoichi Ochi Hidenori Maekawa Toshiro Hayes C Nelson Tateno Chise Yoshizato Katsutoshi Murakami Shoichi Yamashita Nobuyuki Matsuhira Takashi Asai Kenji Chayama Kazuaki |
| Affiliation: | 1 Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima-shi 734-8551, Japan 2 Liver Research Project Center, Hiroshima University, Hiroshima, Japan 3 Laboratory for Digestive Diseases, Center for Genomic Medicine, The Institute of Physical and Chemical Research (RIKEN), Hiroshima, Japan 4 PhoenixBio Co., Ltd., Higashihiroshima, Japan 5 Pharmaceutical Research Center, Meiji Seika Kaisha Ltd., Yokohama, Japan |
| Abstract: | |
| Keywords: | HCV, hepatitis C virus HSA, human serum albumin IFN, interferon IL, interleukin ISG, interferon stimulated gene MxA, myxovirus resistance protein A OAS, oligoadenylate synthetase PKR, double stranded RNA-dependent protein kinase PCR, polymerase chain reaction SCID, severe combined immunodeficiency uPA, urokinase-type plasminogen activator USP18, ubiquitin specific peptidase 18 |
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