DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH |
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| Authors: | Gäbele Erwin Dostert Karin Hofmann Claudia Wiest Reiner Schölmerich Jürgen Hellerbrand Claus Obermeier Florian |
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| Affiliation: | Department of Internal Medicine I, University Medical Center Regensburg, Germany |
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| Abstract: | |
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| Keywords: | NASH, non-alcoholic steatohepatitis DSS, dextran sulfate sodium SC, standard chow HF, high fat IL-1, interleukin 1 TNF, tumor necrosis factor TLR, toll-like receptor MCP-1, monocyte chemoattractant protein 1 TIMP-1, tissue inhibitor of metalloproteinase 1 TGF-β, transforming growth factor beta Pai-1, plasminogen activator inhibitor αSMA, alpha smooth muscle actin LPS, lipopolysaccharide Cramp, cathelin-related antimicrobial peptide NADPH, nicotinamide adenine dinucleotide phosphate CYP2E1, cytochrome P450 2E1 HSC, hepatic stellate cell ROS, reactive oxygen species MCD, methionine-choline deficient |
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