| Glutathione-S-transferase （GSTM1, GSTrl） and the risk of gastrointestinal cancer in a Korean population |
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| 摘 要： |
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| 关 键 词： | GSTM1基因 谷胱甘肽S 胃肠道肿瘤 韩国人 转移酶 风险 人口 聚合酶链反应 |
| 收稿时间： | 2009-09-03 |
Glutathione-S-transferase (GSTM1, GSTT1) and the risk of gastrointestinal cancer in a Korean population |
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| Jin-Mei Piao Min-Ho Shin Sun-Seog Kweon Hee Nam Kim Jin-Su Choi Woo-Kyun Bae Hyun-Jeong Shim Hyeong-Rok Kim Young-Kyu Park Yoo-Duk Choi Soo-Hyun Kim. Glutathione-S-transferase (GSTM1, GSTT1) and the risk of gastrointestinal cancer in a Korean population[J]. World journal of gastroenterology : WJG, 2009, 15(45): 5716-5721. DOI: 10.3748/wjg.15.5716 |
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| Authors: | Jin-Mei Piao Min-Ho Shin Sun-Seog Kweon Hee Nam Kim Jin-Su Choi Woo-Kyun Bae Hyun-Jeong Shim Hyeong-Rok Kim Young-Kyu Park Yoo-Duk Choi Soo-Hyun Kim |
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| Affiliation: | [1]Department of Preventive Medicine, Chonnam National University Medical School, Gwangju 501-746, South Korea [2]Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do 519-809, South Korea [3]Genome Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do 519-809, South Korea [4]Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do 519-809, South Korea [5]Department of Surgery,Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do 519-809, South Korea [6]Department of Pathology, Chonnam National University Medical School, Gwangju 501-746, South Korea [7]Department of Laboratory Medicine, Chormam National University Medical School, Gwangju 501-746, South Korea |
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| Abstract: | AIM: To evaluate the association of glutathione S-transferase mu (GSTM1) and glutathione S-transferase theta (GSTT1) null genotypes with the risk of gastric cancer (GC) and colorectal cancer (CRC) in a South Korean population.METHODS: We conducted a population-based, large-scale case-control study including 2213 GCs, 1829 CRCs, and 1699 controls. Null and non-null genotypes of GSTM1 and GSTT1 were determined using real-time PCR.RESULTS: The null genotypes of GSTM1 and GSTT1 were not significantly associated with elevated risk of gastric (OR = 1.070, 95% CI = 0.935-1.224; OR = 1.101, 95% CI = 0.963-1.259, respectively) or colorectal cancer (OR = 1.065, 95% CI = 0.923-1.228; OR = 1.041, 95% CI = 0.903-1.200, respectively). The frequency of the combined null GST genotype was not different between the two cancer groups and controls. Moreover, smoking, drinking, and age did not modify the association between these genotypes and the risk of gastric or colorectal cancer.CONCLUSION: GSTM1 and GSTT1 null genotypes were not associated with increased risk of GC or CRC in Koreans. |
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| Keywords: | Glutathione S-transferase mu Glutathione S-transferase theta Gastric cancer Colorectal cancer South Korean population |
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