Evaluation of a Commercial PCR Kit for Diagnosis of Cytomegalovirus Infection of the Central Nervous System |
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| Authors: | Adriana Weinberg Debbie Spiers Guan-Yung Cai Christopher M Long Rita Sun and Vince Tevere |
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| Institution: | Pediatric Infectious Diseases, University of Colorado School of Medicine, Denver, Colorado,1. and Roche Molecular Systems, Inc., Branchburg, New Jersey2. |
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| Abstract: | We evaluated the AMPLICOR cytomegalovirus (CMV) PCR kit for the diagnosis of neurologic CMV infections on 43 positive and 112 negative archived cerebrospinal fluid specimens originally tested by an in-house PCR method. The AMPLICOR kit showed sensitivity and specificity of 95 and 100%, respectively, versus the home-grown assay, indicating its utility in this clinical setting. |
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