| Experimental Study on Effect of Cordyceps Sinensis on Renal Protection,Urinary Enzymes and Nephrotox icity of Cyclosporine A in Rats |
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| 作者姓名： | Xue-Zhi Zhao Lei-shi Li |
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| 作者单位： | ZHAO Xue-zhi (Department of Nephrology,Changzheng Hospital,Shanghai (200003))and LI Lei-shi (The General Hospital of Nanjing Military District,Nanjing (210002)) |
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| 摘 要： | Ｅｘｐｅｒｉｍｅｎｔａｌ Ｓｔｕｄｙ ｏｎ Ｅｆｆｅｃｔ ｏｆ Ｃｏｒｄｙｃｅｐｓ Ｓｉｎｅｎｓｉｓ ｏｎ Ｒｅｎａｌ Ｐｒｏｔｅｃｔｉｏｎ,Ｕｒｉｎａｒｙ Ｅｎｚｙｍｅｓ ａｎｄ Ｎｅｐｈｒｏｔｏｘｉｃｉｔｙ Ｏｆ Ｃｙｃｌｏｓｐｏｒｉｎｅ Ａ ｉ...
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Experimental study on effect of Cordyceps sinensis on renal protection, urinary enzymes and nephrotoxicity of cyclosporine a in rats |
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| Authors: | Xue-Zhi Zhao and Lei-shi Li |
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| Institution: | 1. Department of Nephrology, Changzheng Hospital, 200003, Shanghai
2. The General Hospital of Nanjing Military District, 210002, Nanjing
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| Abstract: | Objective: To explore the protective effect ofCordyceps sinensis (CS) on nephrotoxicity of cyclosporine A (CsA) and its mechanism.Methods: The renal function of isolated perfused rats was observed before and after three months treatment by CS.Results: CS could improve the renal function, increase the volume of urine, Na+ and K+ excretion and inulin clearance rate, and reduce the resistance of renal perfusion. It was found that the activities of urinary N-acetyl-β-glucosaminidase (NAG), γ-glutamyl transferase (γ-GT) and lactate dehydrogenase (LDH) were lower in the CS treatment group than those in the control group.Conclusion: CS could protect the kidney from damage against nephrotoxicity of CsA and improve the abnormality of renal hemodynamics. |
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| Keywords: | cyclosporine A Cordyceps sinensis urinary enzymes isolated perfused rat |
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