| 肝细胞肝癌病人血清IL-12、IL-2、sIL-2R水平的相关性 |
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| 引用本文： | 何松青,陈孝平. 肝细胞肝癌病人血清IL-12、IL-2、sIL-2R水平的相关性[J]. 中华普通外科杂志, 2002, 17(4): 211-213 |
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| 作者姓名： | 何松青 陈孝平 |
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| 作者单位： | 430030,武汉,华中科技大学同济医学院附属同济医院肝脏外科中心 |
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| 摘 要： | 目的探讨肝细胞肝癌 (hepatocellularcarcinoma ,HCC)病人血清IL 12、IL 2、sIL 2R水平的相关关系。方法 6 0例HCC病人 ,随机分为 2组。试验组 (30例 )接受IL 2 (IL 2 10 0万U/d× 7d ,静脉点滴注射 )治疗 ;对照组 (30例 )没有接受生物治疗。两组基础治疗基本相似。采用酶联免疫吸附 (ELISA)法检测所有病人治疗前后血清IL 12、IL 2、sIL 2R水平变化。结果血清IL 12水平与血清IL 2水平正相关 ,IL 12与sIL 2R无关 ,IL 2与sIL 2R负相关。IL 2治疗后平均血清IL 12、IL 2、sIL 2R水平显著性升高。IL 2治疗后血清IL 12水平下降的HCC病人预后差。结论IL 12与IL 2之间可能存在一个反馈环路 ,sIL 2R是这个环路的负调节因素。IL 2治疗可刺激内源性IL 12释放。HCC病人的预后可能与IL 2诱生的IL 12变化有关
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| 关 键 词： | 肝细胞癌 生物因子 血清 IL－2 IL－12 sIL－2R 预后 酶联免疫吸附法 |
| 修稿时间： | 2000-12-20 |
Interleukin-2 in its relation with interleukin-12 and soluble interleukin-2 receptor in patients with hepatocellular carcinoma |
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| HE Songqing,CHEN Xiaoping. Hepatic Surgical Center,Affiliated Tongji Hospital of Tongji Medical College,Huazhong University of Science , Technology,Wuhan ,China. Interleukin-2 in its relation with interleukin-12 and soluble interleukin-2 receptor in patients with hepatocellular carcinoma[J]. Chinese Journal of General Surgery, 2002, 17(4): 211-213 |
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| Authors: | HE Songqing CHEN Xiaoping. Hepatic Surgical Center Affiliated Tongji Hospital of Tongji Medical College Huazhong University of Science & Technology Wuhan China |
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| Affiliation: | HE Songqing,CHEN Xiaoping. Hepatic Surgical Center,Affiliated Tongji Hospital of Tongji Medical College,Huazhong University of Science & Technology,Wuhan 430030,China |
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| Abstract: | |
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| Keywords: | Cancer hepatocellular Cytokine |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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