| 黑素瘤细胞体外穿透性体内转移性及tPA释放量研究 |
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| 引用本文： | 陈学良. 黑素瘤细胞体外穿透性体内转移性及tPA释放量研究[J]. 山东大学学报(医学版), 1990, 0(2) |
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| 作者姓名： | 陈学良 |
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| 作者单位： | 山东医科大学血液病研究室 |
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| 摘 要： | tPA是蛋白分解酶类,在肿瘤细胞侵袭和转移中起重要作用。黑素瘤细胞株可释放tPA。我们研究了A_(375)M和A_(375)P两株细胞株的体外穿透性,A_(375)M对基底膜的穿透能力是A_(375)P的4.3倍,体内的转移性前者较后者高,tPA释放量前者多于后者,表明tPA产量和肿瘤细胞的转移性相关。
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| 关 键 词： | 黑素瘤 肿瘤转移 肿瘤侵润力 血纤维蛋白溶酶原激活剂 |
STUDY OF MELANOMA CELL LINES ON PENETRATIVE AND METASTATIC POTENTIAL IN VITRO AND IN VIVO COMPARED WITH TPA PRODUCTION |
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| Chen Xueliang Dept.of Hematological Research Section,Shandong Medical University. STUDY OF MELANOMA CELL LINES ON PENETRATIVE AND METASTATIC POTENTIAL IN VITRO AND IN VIVO COMPARED WITH TPA PRODUCTION[J]. Journal of Shandong University:Health Sciences, 1990, 0(2) |
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| Authors: | Chen Xueliang Dept.of Hematological Research Section Shandong Medical University |
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| Abstract: | Tissue plasminogen activator(tPA)can be produced bymelanoma cells.tPA,a class of proteolytic enzymes,are thought to playan integral role in invasion and metastasis of cancer cells.The invasive andmetastatic potential of A_(375M)and A_(375P)were studied in vitro and in vivo.In the in vitro invasion assay,4.3 fold A_(375M)cells penetrated a syntheticextracellular membrane barrier than A_(375P).When injected into nude mice,A_(375M)produced metastases more frequently than A_(375P).The more aggres-sive A_(375M)cell line secreted more tPA than the relatively indodent A_(375P)cell line.These research provide further evidence that tPA production maybe related to the metastatic capacity of aggressive tumor cells. |
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| Keywords: | Melanoma Neoplasm metastasis Neoplasm invasiveness Plasminogen activators |
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