维生素E、C在CVD与PD患者中抗氧化作用的临床研究

目的 探讨维生素E（Vit E)与维生素C（Vit C)在脑血管病（CVD）与帕金森病（PD）中的抗氧化作用。方法 检测CVD162例和PD77例共239例患者服用VitE和VitC前后血浆Vit E、Vit C、过氧化脂质（LPO）水平和红细胞超氧化物歧化酶（SOD）活性，并与对照组进行了比较。结果 服药前两组患者血浆Vit E、Vit C水平和红细胞SOD活性明显低于正常对照组；服药后两组患者的Vit E、Vit C水平和SOD活性无明显变化，而CVD组的LPO值升高。结论 CVD和PD患者可能有Vit E、Vit C水平和SOD活性降低，服用Vit E、Vit C后仅见CVD患者的LPO值升高，但匀不能象健康对照组那样提高Vit E、Vit C水平和SOD活性。

The clinical research of the antioxidation effects of vitamin E,vitamin C in patients with cerebral vascular disease and Parkinson's disease

Objective To explore the antioxidation effects of vitamin E (Vit E),vitamin C(Vit C) in cerebral vascular disease(CVD) and Parkinson disease(PD). Methods The levels of Vit E,Vit C,lipoperoxides(LPO) and the activity of superoxide dismutase (SOD) were measured in 239 patients with CVD(162cases) and PD (77 cases),and compared with the results of the 32 healthy subjects. Results The result showed that the level of Vit E,Vit C,LPO and the activity of SOD in CVD and PD groups were obviously lower than that of healthy subjects before taking medicine ;There was no significant difference in the level of Vit E,Vit C,LPO and the activity of SOD in both groups after taking Vit E and Vit C except the value of LPO was highily in CVD group. Conclusion The level of Vit E,Vit C and SOD are lower in the patients with CVD and PD. Though the LPO are highly after taking Vit E and Vit C in CVD,it does not rise the Vit E and Vit C level and SOD activity in patients,while in healthy subjects the changes are obviously after taking medicine.