| 全身性红斑狼疮、银屑病和胰岛素依赖性糖尿病病人补体成份BfSS亚型的检测 |
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| 引用本文： | 翦必希,赵修竹,王伟蓁,甘霖,祝希媛,项慧丽. 全身性红斑狼疮、银屑病和胰岛素依赖性糖尿病病人补体成份BfSS亚型的检测[J]. 中国病理生理杂志, 1988, 0(3) |
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| 作者姓名： | 翦必希 赵修竹 王伟蓁 甘霖 祝希媛 项慧丽 |
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| 作者单位： | 同济医科大学病理生理学教研室(翦必希，赵修竹)，武汉市第一医院皮肤科(王伟蓁，甘霖)，北京友谊医院(祝希媛)，北京友谊医院(项慧丽) |
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| 摘 要： | 用薄层聚丙烯酰胺凝胶等电聚焦方法对62例全身性红斑狼疮(SLE)、61例寻常型银屑病(PV)及17例胰岛素依赖性糖尿病(IDDM)病人补体第二途径成份B因子SS型的亚型分布及基因频率进行了检测。结果表明,SLB病人BfSS亚基因频率分别为,S_A0.516,S_B0.484;PV为:S_A0.492,S_B0.508,IDDM为:S_A0.676,S_B0.324。与正常人(S_A0.414,S_B0.586)比较,三种疾病的S_A亚基因频率均有不同程度的增高,并伴有S_B亚基因频率的降低。统计结果表明,IDDM与正常人的差异显著(P<0.01),SLE次之(P<0.05),PV不著(P>0.1)。此外,这三种疾病病人BfS_A-S_A亚型的表型频率(分别为30.6%、31.1%和41.1%)都显著高于正常19.3%),统计学表明差异均显著(P<0.05)。
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| 关 键 词： | 补体成份 备解素因子B类 红斑狼疮 全身性 牛皮癣 糖尿病 胰岛素依赖型 |
Sybtyping of BfSS phenotype in patients with SLE, PV and IDDM |
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| Jian Bi-Xi,et al Departmeut of Pathophysiology,Tongji Medical University,Wuhan. Sybtyping of BfSS phenotype in patients with SLE, PV and IDDM[J]. Chinese Journal of Pathophysiology, 1988, 0(3) |
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| Authors: | Jian Bi-Xi et al Departmeut of Pathophysiology Tongji Medical University Wuhan |
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| Abstract: | The subtypes of BfSS phenotype in patients with SLE, PV and IDDM were investigated using the isoelectrofocusinq technigue; Subgene frequencies for 62 SLE patients with BfSS phenotype are 0.516 for S_A. and 0.484 for S_B. The 61 PV patients with BfSS phenotype are 0.492 for S_A, and 0.508 for S_B. The 17 IDDM patients with BfSS phenotype are 0.676 for S_A, and 0.324 for S_B. Significant increase tn subgene frequencies of BfS_A in patients with IDDM and SLE were found in comparison with that In the controls. In addition, increase in BfS_A-S_A phenotype frequencies were observed for SLE, PV and IDDM. These results suggest that there are some positive association with BfSA in these diseases. |
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| Keywords: | Complement properdin factor B Lupus erythematosus systemic Psoriasis Diabetes mellitus insulin-dependent |
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