| 银杏叶提取物对大鼠脑缺血的保护作用 |
| |
| 引用本文： | 沈明勤,叶其正,罗宇慧,陆泽安. 银杏叶提取物对大鼠脑缺血的保护作用[J]. 中国药学杂志, 2003, 38(9): 673-675 |
| |
| 作者姓名： | 沈明勤 叶其正 罗宇慧 陆泽安 |
| |
| 作者单位： | 江苏省中医药研究院中药药理毒理研究室,江苏,南京,210028 |
| |
| 摘 要： | 目的观察银杏叶提取物(简称EGb)静脉注射给药后，对不完全性脑缺血大鼠的保护作用，并探讨其抗脂质过氧化作用。方法采用双侧颈总动脉结扎造成大鼠不完全性脑缺血模型；通过生化手段，对脑组织中与脂质过氧化有关的一些指标进行检测。结果EGb可降低脑缺血大鼠的脑梗死区重量、脑含水量，增强脑组织中SOD的活性，减少MDA的含量，并可降低脑毛细血管通透性。结论EGb对实验性大鼠脑缺血具有保护作用，并有抗脂质过氧化的作用。
|
| 关 键 词： | 银杏叶 脑缺血 脂质过氧化 |
| 文章编号： | 1001-2494(2003)09-0673-03 |
| 收稿时间： | 2002-10-14; |
| 修稿时间： | 2002-10-14 |
Protective effects of extract Ginkgo bilola on brain ischemia in rats |
| |
| SHEN Ming-qin,YE Qi-zheng,LUO Yu-hui,LU Ze-an. Protective effects of extract Ginkgo bilola on brain ischemia in rats[J]. Chinese Pharmaceutical Journal, 2003, 38(9): 673-675 |
| |
| Authors: | SHEN Ming-qin YE Qi-zheng LUO Yu-hui LU Ze-an |
| |
| Affiliation: | Department of Pharmacology and Toxicology,Jiangsu Provincial Academy of Traditional Chinese Medicine,Nanjing 210028,China |
| |
| Abstract: | OBJECTIVE To study the protective effects of EGb injection on brain ischemia in rats.METHODS The imperfectible brain ischemia model was produced in rats by occluding the double internal carotid.Some indices related to lipid peroxidation of brain tissue were measured with biochemical methods.RESULTS The infarct size and the water content in the brain tissue with brain ischemia were reduced.It also elevated the activity of SOD and decreased the MDA contents in brain tissue.The permeability of capillary vessel was decreased.CONCLUSION EGb can protect the injury of brain ischemia of rats.Its mechanism may be due to the anti-peroxidative function of lipid. |
| |
| Keywords: | Ginkgo bilola brain ischemia lipid peroxidation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国药学杂志》浏览原始摘要信息 |
|
点击此处可从《中国药学杂志》下载免费的PDF全文 |
