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Long-term potentiation in the optic tectum of rainbow trout |
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| Authors: | Kinoshita Masae Hosokawa Toshiyuki Urano Akihisa Ito Etsuro |
| Affiliation: | aDivision of Biological Sciences, Graduate School of Science, Hokkaido University, North 10, West 8, Kita-ku, Sapporo 060-0810, Japan bCenter for Research and Development in Higher Education, Hokkaido University, Sapporo 060-0817, Japan cDivision of Innovative Research, Creative Research Initiative “Sousei” (CRIS), Hokkaido University, Sapporo 001-0021, Japan |
| Abstract: | We examined synaptic plasticity in the optic tectum of rainbow trout by extracellular recordings. We found that the field-excitatory postsynaptic potential in the retinotectal synapses was potentiated by repetitive stimuli of 1.0 Hz for 20 s to the retinotectal afferents. The long-term potentiation (LTP) developed slowly, and was maintained for at least 2 h. Applications of an antagonist for N-methyl-D-aspartic acid (NMDA) receptors or Mg2+-free saline showed that activation of NMDA receptors was required to form the LTP beyond the induction period. The present findings indicate that presynaptic stimulation in the retinotectal synapses causes LTP mediated by NMDA receptors in the optic tectum of rainbow trout. |
| Keywords: | Glutamate receptor AMPA NMDA Periventricular neuron Teleost |
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