In vitro activity of cefpodoxime against bacterial isolates obtained from patients with cancer |
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| Authors: | K. V. I. Rolston M. Messer H. Nguyen D. Ho B. LeBlanc G. P. Bodey |
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| Affiliation: | (1) Section of Infectious Diseases, Department of Medical Specialties, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA |
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| Abstract: | The in vitro activity of cefpodoxime, an oral cephalosporin ester, against 792 bacterial isolates representing 36 species was evaluated in comparison to that of ciprofloxacin and trimethoprim/sulfamethoxazole (TMP/SMX). Cefpodoxime inhibited the majority ofStreptococcus spp.,Haemophilus influenzae andProteus mirabilis at a concentration of  0.12 µg/ml. It was also active againstCitrobacter diversus, Escherichia coli, Klebsiella spp.,Proteus vulgaris, Serratia marcescens and methicillin-susceptibleStaphylococcus aureus isolates. Overall, cefpodoxime appeared to be less active than ciprofloxacin and TMP/SMX against many pathogens common in cancer patients. |
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