In Vitro Synergy of Caspofungin and Amphotericin B against Aspergillus and Fusarium spp. |
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| Authors: | Sevtap Arikan Mario Lozano-Chiu Victor Paetznick John H. Rex |
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| Affiliation: | Division of Infectious Diseases, Department of Internal Medicine, Center for the Study of Emerging and Reemerging Pathogens, University of Texas Medical School, Houston, Texas 77030, USA. sarikan@metu.edu.tr |
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| Abstract: | We investigated the in vitro interaction of caspofungin and amphotericin B for clinical isolates of Aspergillus and FUSARIUM: Synergy tests were performed using the checkerboard method and following the NCCLS M38-P guidelines in Antibiotic Medium 3 broth supplemented to 2% glucose. Antagonism was not observed for any of the isolates tested. Caspofungin and amphotericin B were synergistic or synergistic to additive for at least half of the isolates. |
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