中西医结合治疗口腔扁平苔藓的临床疗效观察

目的:观察帕夫林联合醋酸曲安奈德治疗口腔扁平苔藓(OLP)的效果.了解中药制剂帕夫林对OLP患者治疗前后T淋巴细胞亚群的影响.方法:60例OLP患者随机分成两组,A组:30例,醋酸曲安奈德局部病损区内注射,每周一次,共4次,加用帕夫林口服每次2片,每天2次,共2个月;B组:30例,醋酸曲安奈德局部病损区内注射,每周一次,共4次.结果:A组和B组近、远期有效率分别为 90.00%、53.33% (P＜0.01);59.26 %、22.22%(P＜0.05);年复发率分别为40.74%,77.78%(P＜0.05).两组疗效差异有显著性.OLP患者治疗前外周血CD3、CD8比率高于正常人,CD4、CD8比率低于正常人,加用帕夫林治疗后,其比值恢复正常.结论:中西医结合治疗OLP较单纯应用西药疗效好,复发率低.

Curative effects of combined traditional Chinese and western medicine treatment on oral lichen planus

Objective:To observe the effects of total glucosides of paenia(TGP) combined with triamcinolone acetonide acetate on patients with oral lichen planus(OLP).Methods:Sixty OLP patients were divided into two groups.Group A(30 cases) were treated with triamcinolone acetonide acetate injection once a week for a month,and were given 2 tablets of TGP twice a day for 2 months.Group B(30 cases) were given triamcinolone acetonide acetate injection alone.Results:A short-term effctive rate:(90.00%) in Group A and 53.33% in Group B(P<0.01),a long-term effctive rate: 59.26% in Group A and 22.22% in Group B(P<0.05),and an annual relapse rate:40.74% in Group A and 77.78% in Group B(P<0.05).Before the treatment,the peripheral blood CD3/CD8 ratio of patients with OLP was significantly increased,while the CD4/CD8 ratio was significantly decreased,compared with health people(P<0.05).Having added TGP in the treatment,both the CD3/CD8 ratio and the CD4/CD8 ratio of the patients were recovered to normal after treatment.Conclusion:The combined traditional Chinese and western medicine treatment of oral lichen planus is more effective than the western medicine treatment alone and the relapse rate is lower.