First description of an RND-type multidrug efflux pump in Achromobacter xylosoxidans, AxyABM |
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| Authors: | Bador Julien Amoureux Lucie Duez Jean-Marie Drabowicz Anthony Siebor Eliane Llanes Catherine Neuwirth Catherine |
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| Affiliation: | Department of Bacteriology, University Hospital of Dijon, BP 37013, 21070 Dijon Cedex, France. |
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| Abstract: | Achromobacter xylosoxidans is an emerging pathogen in cystic fibrosis patients. The multidrug resistance of these bacteria remains poorly understood. We have characterized in a clinical strain the first resistance-nodulation-cell division (RND)-type multidrug efflux pump in this species: AxyABM. The inactivation of the transporter component axyB gene led to decreased MICs of cephalosporins (except cefepime), aztreonam, nalidixic acid, fluoroquinolones, and chloramphenicol. |
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