Allelic loss during progression of follicular lymphoma |
| |
Authors: | Takeuchi Seisho de Vos Sven Takeuchi Naoko Fermin Anthony C Grogan Thomas M Seo Hiromi Said Jonathan W Koeffler H Phillip |
| |
Affiliation: | Department of Medicine, Kochi University, Okohcho, Nankoku, Kochi 783-8505, Japan. takeuti@kochi-ms.ac.jp |
| |
Abstract: | We performed loss of heterozygosity (LOH) analysis on matched lymph nodes before and after progression of follicular lymphoma (FL), and found novel LOH on chromosome arm 12p. This LOH has not been previously reported in association with FL transformation. Other sites of frequent LOH include chromosome arms 6q and 9p. LOH was observed in both transformed FL and relapse FL. These data suggest that altered tumor suppressor genes exist on 6q, 9p, and 12p that have an important role in the progression of FL. Genetic changes accumulated in relapsed FL in the absence of histological changes compared to initial diagnosis. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|