钙离子拮抗剂致药物性牙龈增生的危险因素分析

目的调查高血压患者服用钙离子拮抗剂后引起药物性牙龈增生的患病率,并分析其危险因素。方法将北京医院心血管内科的681例高血压或冠心病患者纳入本研究,其中330例服用钙离子拮抗剂(CCB组),351例未服用钙离子拮抗剂(对照组)。记录患者的性别、年龄、用药种类、持续时间、剂量、是否联合用药。临床检查牙龈出血指数(BI)、菌斑指数(PLI)、牙龈增生指数(HI)。结果服用钙离子拮抗剂组牙龈增生的患病率为41.21%,显著高于对照组4.84%(P<0.05)。对调查的各种因素进行Logistic回归分析,结果显示:BI(OR=2.17,95%可信区间:1.60-2.94)PLI(OR=1.99,95%可信区间:1.38-2.87)是患者出现牙龈增生的危险因素。结论口腔卫生状况和牙龈炎症反应是药物性牙龈增生的危险因素。

Analysis of risk factors for gingival hyperplasia induced by calcium channel blockers

Objective To investigate the prevalence and risk factors of calcium channel blockers induced gingival overgrowth in hypertensive patients.Methods A cross-sectional survey was conducted in 681 hypertensive patients.Among them 330 patients took calcium channel blockers and 351 patients who had never received calcium channel blockers were recruited as controls.The pharmacological and demographic data for each subject were recorded.Degree of gingival hyperplasia、plaque index and probing bleeding index were studied.Results The prevalence of gingival overgrowth was 41.21% in CCB group which was statistically higher than that（4.84%） in the control group.By Logistic regression analysis BI（OR=2.17,95% CI：1.60-2.94） and PLI（OR=1.99,95% CI：1.38-2.87） were found to be risk factors.Conclusion The gingival inflammation and oral hygiene are important risk factors for the occurrence of gingival hyperplasia induced by calciun channel blockers.