曲安奈德与卡介苗多糖核酸联合治疗糜烂型OLP疗效观察

目的观察曲安奈德联合卡介苗多糖核酸治疗糜烂型口腔扁平苔藓(OLP)的临床疗效。方法将48例OLP患者随机分为治疗组和对照组,每组24例。治疗组行病变区局部注射曲安奈德,每周1次,4周为一个疗程,同时进行卡介苗多糖核酸肌肉注射,隔日1次,4周为一个疗程;对照组单用曲安奈德行局部注射治疗,一个疗程后观察两组临床疗效。结果治疗组总有效率87.50%,对照组总有效率79.17%,两组间比较无明显差异(P>0.05)。治疗后6个月治疗组和对照组的复发率分别为7.69%和30.0%,组间比较有明显差异(P<0.05)。治疗后1年治疗组和对照组的复发率分别为38.46%和60.0%,组间比较无明显差异(P>0.05)。结论卡介苗多糖核酸联合曲安奈德注射治疗糜烂型OLP,可在一定程度上降低复发率,提高临床疗效。

The treatment effect of BCG-PSN and triamcinolone acetonide on erosive oral lichen planus by

Objective To observe the treatment effect of triamcinolone acetonide（TA） and BCG Polysaccharide Nucleic Acid（BCG-PSN） on erosive oral lichen planus.Methods 48 patients with oral lichen planus were randomly divided into 2 groups.Treatment group： 24 cases received TA in lesion areas,the injection were repeated every week,this process was repeated for 4 weeks.At the same time,they also received BCG-PSN by intramuscular injection,repeated every two days,and this process was repeated for 4 weeks while in the control group 24 cases only received TA as the treatment group.Results The total effective rate was 87.50% in the treatment group.In the control group,the total effective rate was 79.17%.The differences between two groups were not statistically significant（P0.05）.The recurrence rate in two groups after 6months was 7.69% and 30.0% respectively.There was significant difference between two groups（P0.05）.The recurrence rate in two groups after 12 months was 38.46% and 60.0% respectively.The differences between two groups were not statistically significant（P0.05）.Conclusion To a certain extent,the BCG Polysaccharide Nucleic Acid and TA are effective in treating patients with erosive oral lichen planus and reducing the recurrence rate.