糖尿病患者视网膜血管血氧饱和度变化研究

目的 观察糖尿病患者与健康人群视网膜血管血氧饱和度的差异.方法 临床确诊为糖尿病的71例(71眼)患者和91名(91眼)健康者分别纳入糖尿病组和正常组.采用视网膜血管血氧饱和度测量仪检测两组受检者,并应用仪器配套软件分析距离视盘中心1.5-3.0个视盘直径的视网膜动脉、静脉血氧饱和度值.结果 71例糖尿病患者中,男性与女性、各个年龄段、不同糖尿病病程间比较,视网膜动脉、静脉及其各象限分支动脉、静脉的血氧饱和度差异均无统计学意义(均为P ＞0.05).糖尿病组视网膜动脉血氧饱和度较正常组显著升高(P=0.00);糖尿病组视网膜动脉各象限的血氧饱和度均较正常组高,其中颞上分支、颞下分支与正常组相比差异均有统计学意义(均为P ＜0.05).糖尿病组视网膜静脉血氧饱和度较正常组有升高的趋势,但差异无统计学意义(P＞0.05);糖尿病组视网膜静脉血氧饱和度颞上分支、颞下分支较正常组高,鼻下分支较正常组低,差异均有统计学意义(均为P ＜0.05).糖尿病组视网膜动静脉血氧饱和度差值较正常组显著升高(P=0.00).结论 糖尿病患者视网膜血管血氧饱和度与健康人群存在显著差异;糖尿病患者不同象限的血管血氧饱和度存在不同程度的改变,提示视网膜氧代谢异常程度在各象限的分布并不均匀.

Changes of retinal vessel oxygen saturation in diabetic patients

Objective To observe the differences of retinal vessel oxygen saturation between diabetic and healthy subjects.Methods Seventy-one diabetic patients and 91 healthy persons were included diabetes group and control group respectively.Oxygen saturation was measured in retinal blood vessels in two groups using retinal Oxymap.The oxygen saturation in retinal arteries and veins about 1.5-3.0 disc-diameter from center of optic disc was analyzed by instrumental software.Results Among 71 cases of diabetics,there was no significant difference in retinal oxygen saturation between male and female,among different ages and duration of disorder (all P ＞ 0.05).The retinal average arteriolar oxygen saturation in diabetes group was higher than that in control group (P =0.00).The diabetes group had the higher arteriolar oxygen saturation in all the quadrants,while only the superior temporal and inferior temporal showed significant difference statistically (all P ＜0.05).The retinal average venous oxygen saturation in diabetes group showed an upward trend although with no significance (P ＞0.05).Venous oxygen saturation in the diabetes group were higher in retinal superior temporal and inferior temporal quadrant and lower in retinal inferior nasal quadrant,there were significant statistical differences (all P ＜ 0.05).The retinal arterio-venous oxygen saturation differences in diabetes group was higher than that in control group,there was significant statistical difference (P =0.00).Conclusion There is significant difference in retinal vessel oxygen saturation between diabetics and healthy subjects.There are different degrees of changes in retinal oxygen saturation among different quadrants,indicating uneven distribution of retinal oxygen metabolism in each quadrant.