A Case Study: Refractory Recurrent Autoimmune Hepatitis Following Liver Transplantation in Two Male Patients |
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Authors: | V. TenCate R. Komorowski D. Cronin J. Hong S. Gawrieh |
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Affiliation: | 1. Department of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA;2. Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA;3. Department of Transplant Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA |
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Abstract: | Autoimmune hepatitis (AIH) recurs after liver transplantation and significantly impacts graft function and patient survival. In this case report, we present 2 cases of male patients with refractory recurrent AIH after liver transplantation. Each patient lost their first graft due to refractory continuous AIH. We have not noticed a similar refractory course for our female patients with AIH post-transplantation at our center. Based on our single-center experience there appears to be a gender disparity in the aggressive nature of AIH recurrence after transplantation. Despite the aggressive nature of recurrent AIH in both patients, graft loss occurred beyond 3 years for both patients and did not influence the 1- and 3-year patient survival. If these findings are validated, they may have significant impact on post-transplantation immunosuppression management in male patients. |
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