首页 | 本学科首页   官方微博 | 高级检索  
     


Association of IL-17F Gene Polymorphisms With Renal Transplantation Outcome
Authors:H. Park  S. Shin  M.H. Park  Y.S. Kim  C. Ahn  J. Ha  E.Y. Song
Affiliation:1. Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea;2. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea;3. Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
Abstract:

Objective

Although interleukin 17 (IL-17) has some roles in renal transplantation, the influence of IL-17 gene single-nucleotide polymorphisms (SNPs) on renal transplantation has not been studied.

Methods

The associations of 5 IL-17F gene SNPs (–1507G/A, 6329G/A, 7384A/G, 7470G/A, and 7489A/G) with renal transplantation outcome were analyzed. Polymerase chain reaction with sequence-specific primers (for –1507G/A and 6329G/A) and direct sequencing (for 7384A/G, 7470G/A, and 7489A/G) were performed on 282 renal transplantation recipients and 210 healthy controls.

Results

IL-17F SNPs were not associated with acute rejection. Recipients with G allele on 7489A/G showed lower graft survival than recipients without G allele (P = .04). In multivariate analysis, G allele on 7489A/G was an independent risk factor for graft failure (odds ratio = 2.77, P = .03).

Conclusion

IL-17F gene SNP 7489A/G was associated with renal graft failure. Further studies are needed in larger number of patients.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号