Association of IL-17F Gene Polymorphisms With Renal Transplantation Outcome |
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| Authors: | H. Park S. Shin M.H. Park Y.S. Kim C. Ahn J. Ha E.Y. Song |
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| Affiliation: | 1. Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea;2. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea;3. Department of Surgery, Seoul National University College of Medicine, Seoul, Korea |
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| Abstract: | ObjectiveAlthough interleukin 17 (IL-17) has some roles in renal transplantation, the influence of IL-17 gene single-nucleotide polymorphisms (SNPs) on renal transplantation has not been studied.MethodsThe associations of 5 IL-17F gene SNPs (–1507G/A, 6329G/A, 7384A/G, 7470G/A, and 7489A/G) with renal transplantation outcome were analyzed. Polymerase chain reaction with sequence-specific primers (for –1507G/A and 6329G/A) and direct sequencing (for 7384A/G, 7470G/A, and 7489A/G) were performed on 282 renal transplantation recipients and 210 healthy controls.ResultsIL-17F SNPs were not associated with acute rejection. Recipients with G allele on 7489A/G showed lower graft survival than recipients without G allele (P = .04). In multivariate analysis, G allele on 7489A/G was an independent risk factor for graft failure (odds ratio = 2.77, P = .03).ConclusionIL-17F gene SNP 7489A/G was associated with renal graft failure. Further studies are needed in larger number of patients. |
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