对氧磷酶-1活性与冠状动脉病变支数的相关性研究

目的 探讨血清对氧磷酶-1（PON-1）活性与冠状动脉病变支数的关系。方法 212例按冠状动脉造影结果分为冠状动脉狭窄（CHD^＋）组（151例）和冠状动脉正常（CHD^-）组（61例），并根据冠状动脉病变程度将CHD。组分为单支病变组（34例）．双支病变组（46例），三支病变组（71例）。分光光度法测定血清PON-1活性；分析PON-1活性与冠状动脉病变支数的关系。结果 冠心病组血清PON-1活性明显低于对照组（t=17．25，P〈0．0001）；血清PON-1活性单支病变组明显高于双支、三支病变组（F=9．536，P〈0．05）；而双支和三支病变组比较差异无统计学意义（P=0．13）。结论 冠心病患者血清PON-1活性水平明显降低，随着病变程度加重，血清PON-1活性水平降低。

RELATIONSHIP OF PARAOXONASE - 1 ACTIVITY AND NUMBER OF STENOSED CORONARY ARTERY LESIONS VESSELS

Objective To explore the relationship of activity of paraoxonase-1(PON-1) in coronary artery disease and the number of stenosed coronary artery lesions vessels in coronary artery disease(CAD) patients.Methods 212 subjects were investigated in this study,including 61 healthy subjects,151 cases who were confirmed as CAD by coronary angiography,including stable angina,old myocardial infarction,unstable angina.CAD cases were divided into single vessel(n=34),double vessel(n=46) and triple vessel(n=71) group.The activity of PON-1 were determined by spectro photometry.Results The activity of PON-1 were lower in CAD group than those in non-CAD group(t=17.25,P<0.001).The relationship between the activity of PON-1 and involved branch numbers of coronary arteries had statistically relationship(F=9.356,P<0.05).The activity of PON-1 were higher in single branch group than those in double and three branch group(P<0.05).But there is no significant difference between two branch group and three branch group(P=0.13).Conclusion The study shows that the activity of PON-1 is lower in CAD group than that in non-CAD group.The relationship between activity of PON-1 and severity of the coronary artery atherosclerosis lesions has negative correlation.