胎儿生长受限孕妇血及脐血内脂质过氧化物和一氧化氮水平

目的探讨母血及脐血中脂质过氧化物(LPO)和一氧化氮(NO)水平与胎儿生长受限(FGR)发生的关系及其临床应用价值。方法取38例妊娠合并FGR(FGR组)及50名正常孕妇(对照组)肘静脉血及其新生儿脐血,应用改良的硫代巴比妥酸(TBA)法测定血清LPO水平;应用硝酸盐还原酶法测定血清NO水平。结果FGR组患者血LPO和NO水平与对照组相比均显著升高(P<0.01),其新生儿脐血LPO和NO水平也显著升高(P<0.001)。两组孕妇母血、脐血中LPO和NO水平均呈正相关(P均<0.01)。结论LPO和NO均可能参与了FGR的发病,检测母血及脐血中LPO和NO水平可作为FGR的辅助诊断指标之一。

The levels of lipid peroxide and nitric oxide in maternal and umbilical serum in pregnant women with fetal growth restriction

Objective To investigate the relationship between the levels of maternal and umbilical serum lipid peroxide(LPO)and nitric oxide(NO)and fetal growth restriction(FGR) and its clinical significance. Methods 38 pregnant women with FGR(FGR group) and 50 normal pregnant women in late trimester(normal control group) were studied.Maternal and fetal umbilical venous blood samples were collected from all the cases.The level of serum LPO was measured by improved thiobarbituric acid fluorescence analysis.The level of serum NO was measured by the Griess reaction after reduction with nitrate reductase. Results Compared with the control,maternal as well as umbilical serum LPO and NO in FGR group were significantly higher(P<0.01 and P<0.001 respectively).There was correlation between LPO and NO concentration in both groups. Conclusions LPO and NO in the pregnant women and their fetus may play an important role in pathogenesis of FGR.LPO and NO levels in the maternal and umbilical serum may be potential markers for FGR diagnosis.